The figure, published by Germany’s Robert Koch Institute (RKI), surpasses the last high, which had been 197.6 reached on December 22, 2020.
While many more people in the country have had the jab than at that point last year, vaccination rates have stagnated at under 70 percent, with officials pleading in the last days for the population to get the jab.
“For the unvaccinated, the risk is high that they will become infected in the coming months,” warned RKI chief Lothar Wieler on Wednesday.
In the eastern state of Saxony, where the incidence rate is more than twice the national average at 491.3, unvaccinated people face new restrictions from Monday.
Access to indoor dining and other indoor events will be limited to those who are fully vaccinated or can show proof of recovery.
The new rules are the toughest state-wide restrictions in Germany against non-inoculated people. Only children as well as those who cannot receive jabs for medical reasons will be exempt.
The surge in German cases comes with the country in political limbo following September’s general election.
The incoming coalition parties, aiming to form a government by early December, have so far ruled out mandatory jabs and said there will be no new lockdowns — at least not for the vaccinated.